文献名： Plasmonic photothermal microneedle arrays and single needles for minimally-invasive deep in-skin hyperthermia

作者： Álvaro Cárcamo-Martínez ^a, Brónach Mallon ^a, Juan Domínguez-Robles ^a, A. Sara Cordeiro ^a, Maurizio Celentano ^b, Eneko Larrañeta ^a, Steven E. J. Bell ^b and Ryan F. Donnelly *^a

^aSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK. E-mail:

^bSchool of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast BT9 5AG, UK

摘要：We report, for the first time, crosslinked polymeric microneedle (MN) arrays and single needles (2 mm and 4.5 mm length) coated with gold nanorods (GnRs) to induce deep hyperthermia in a 3 mm-thickness skin model upon near infrared (NIR) laser irradiation. Using excised neonatal porcine skin as tissue model, it was seen that insertion capabilities of single prototypes were not affected by the coating, as around 80% of their length was inserted before and after coating. Insertion of MN arrays dropped from 74% to 55%, which could be attributed to a less sharp structure after the coating process. Nonetheless, GnRs-coated MN arrays achieved the highest increase in temperature in the skin model: over 15 °C after only 15 s of NIR laser irradiation (808 nm, 2 W cm⁻²). Surprisingly, removal of MN arrays after irradiation left no detectable polymer or plasmonic material behind, confirming the enhanced safety and minimally-invasive potential of this device for future biomedical applications of deep in skin hyperthermia.