文献名： Potential of Polymeric Films Loaded with Gold Nanorods for Local Hyperthermia Applications

作者： Álvaro Cárcamo-Martínez 1 , Juan Domínguez-Robles 1 , Brónach Mallon 1 , Md. Taifur Raman 2, Ana Sara Cordeiro 1 , Steven E. J. Bell 2 , Eneko Larrañeta 1 and Ryan F. Donnelly 1

1 School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK;

2 School of Chemistry and Chemical Engineering, Queen’s University Belfast, Belfast BT9 5AG, UK;

摘要：Current strategies for the treatment of superficial non-melanoma skin cancer (NMSC) lesions include topical imoquimod, 5-fluorouracil, and photodynamic therapy. Although these treatments are effective, burning pain, blistering, and dermatitis have been reported as frequent side effects, making these therapies far from ideal. Plasmonic materials have been investigated for the induction of hyperthermia and use in cancer treatment. In this sense, the effectiveness of intratumorally and systemically injected gold nanorods (GnRs) in inducing cancer cell death upon near-infrared light irradiation has been confirmed. However, the in vivo long-term toxicity of these particles has not yet been fully documented. In the present manuscript, GnRs were included in a crosslinked polymeric film, evaluating their mechanical, swelling, and adhesion properties; moreover, their ability to heat up neonatal porcine skin (such as a skin model) upon irradiation was tested. Inclusion of GnRs into the films did not affect mechanical or swelling properties. GnRs were not released after film swelling, as they remained entrapped in the polymeric network; moreover, films did not adhere to porcine skin, altogether showing the enhanced biocompatibility of the material. GnR-loaded films were able to heat up the skin model over 40 °C, confirming the potential of this system for non-invasive local hyperthermia applications

关键词：non-melanoma skin cancer; hyperthermia; gold nanorods; polymeric films; near infrared light; heating studies